High-risk infants (referred to as high-risk infants) are newborns who have been exposed to various high-risk factors during the neonatal period and have developed or are likely to develop critical diseases. Commonly seen high-risk infants include: preterm infants with gestational age <37 weeks, low birth weight infants with birth weight <2500 g, intrauterine malnutrition, intrauterine distress, ischemic-hypoxic encephalopathy, intracranial hemorrhage, persistent hypoglycemia, persistent hypoxemia, neonatal hemolysis, sepsis, hyperbilirubinemia, brain abnormalities on imaging, and obstructed labor during delivery. Through monitoring and screening of high-risk children, early detection of physical growth or developmental deviations, early assessment, diagnosis, and guided interventions can reduce the incidence of physical growth and developmental behavioral problems and disabilities in children, promote the overall physical-motor, language, cognitive, and social-emotional development of children, and improve the quality of life of children with these problems. Early manifestations of children at risk: 1. crying all day, sleeplessness, easily startled, easily provoked or excessively quiet, frequent shaking of head, jaw and limbs; 2. 2. Feeding difficulties, frequent spitting up and choking; 3. The infant's arms and legs are often flexed or straightened and jerked; 4. Strong reaction to sound and light or no reaction. 6.Not looking at the face when feeding, inflexible eye rotation. 7. Excessive tension of limbs (stick-like) or excessive flabbiness. 8.Still clenching fist at 4 months, thumb close to palm and inward. Management of high-risk infants: Routine follow-up after discharge: once every 6 months, once every 2 months from 6 to 12 months, and once every 3 months from 12 to 24 months of age. Timely guidance on healthy feeding was received from physicians, and comprehensive rehabilitation interventions were provided as soon as developmental deviations were detected.