Tuberous sclerosis is a hereditary disease, often involving multiple systems, the prognosis is generally poor, and its treatment mainly includes drug therapy and surgical treatment. 1. Drug therapy: tuberous sclerosis usually presents with neurological damage before general drug therapy is considered. Neurological damage is mainly epilepsy, with infantile spasms being the most common, so antiepileptic drugs, such as aminocaproic acid and adrenocorticotropic hormone, etc., are needed. In addition, targeted drugs such as rapamycin and sirolimus can be used. 2. Surgery: For intractable epilepsy that is not well controlled by medication, surgery can be considered, such as focal epileptic lesion resection and vagus nerve stimulation. Surgical resection can also be performed for the presence of giant neurofibromas of the skin. The treatment of tuberous sclerosis is a holistic approach and the opinion of the local attending physician should be respected.