We are often asked about whether patients with epilepsy can be vaccinated, especially recently because of influenza A (H1N1), which is gradually being vaccinated, and more and more people are concerned. Based on some experience at work and frequent communication with internists and pediatricians during consultations, and after checking some information, there are a few points for your reference: 1. Actually, I have not seen any studies on vaccination of epilepsy patients, which is quite understandable, after all, you cannot specifically go for trials in this area. So there are only theoretical considerations and a few case reactions. 2. Most doctors are not really able to answer this question. They can only say “ask the doctor in charge of the vaccination” or “check the vaccine instructions”. However, other doctors are also not good at answering this question, and the manual does not mention this or only says “use with caution”, so in order to avoid responsibility, they simply do not use it, or let the family bear the consequences. 3. In my experience, vaccines related to neurological diseases may theoretically aggravate seizures or even cause seizures, such as B encephalitis vaccine, rheumatoid vaccine, and diphtheria vaccine (mainly tetanus vaccine). The other commonly used vaccines have not been shown to be associated with seizures, so they can be administered. Of course, some uncomfortable symptoms such as fever may occur after vaccination, which may aggravate seizures in epilepsy patients, as a result of fever, not related to the type of vaccine. 4. Are the three vaccines mentioned above (B encephalitis vaccine, rheumatoid brain vaccine and diphtheria vaccine) not suitable for children with epilepsy? My personal opinion is debatable. Theoretically, regular and qualified vaccines are not toxic and only activate autoimmunity. It is true that a few patients with epilepsy have experienced exacerbation of seizures after vaccination with the above vaccine, but there is not enough evidence to suggest that it is necessarily exacerbated, and the mechanism of exacerbation is not clear. However, if not vaccinated, the consequences of being infected can be severe (even fatal)! From the point of view of “choosing the lesser of two evils”, I think we should choose vaccination (of course, it should be noted that we cannot be held responsible and we are responsible for the consequences). The above comments are discussed from the perspective of epilepsy patients, and there are some contraindications to vaccination in general (such as allergies, fever, etc.), so I won’t go into them here.