Positive gynecologic leukocyte esterase does not confirm the diagnosis of a specific gynecologic disorder, but suggests the presence of gynecologic inflammation in a woman, and the cause should be clarified promptly. Leukocyte esterase is a specific enzyme secreted by neutrophils, which is not expressed in a healthy state and is negative. If there is inflammatory disease in the patient’s body, neutrophils can secrete leukocyte esterase in order to resist the attack of external pathogenic bacteria, and then leukocyte esterase can appear positive. Therefore, a positive leukocyte esterase test in women only indicates the presence of inflammation in the body and does not directly confirm the diagnosis of a specific disease. Normally, leukocyte esterase is one of the routine tests for leukorrhea in female patients. When leukocyte esterase is positive, it suggests the presence of pelvic inflammatory disease or vaginal inflammation, and further examination is needed to clarify the specific type of inflammation and to choose the appropriate medication to treat it. It is important to note that the use of medication needs to be under the guidance of a professional physician, so as not to blindly use drugs to avoid adverse consequences.