5, angiotensin II receptor antagonists, cloxacin, irbesartan; 6, alpha 1 receptor blockers, prazosin, terazosin; 7, central antihypertensive drugs. In the clinic often patients have a variety of comorbidities and special circumstances, bringing confusion to our drug selection. In the face of a variety of patients and a wide variety of drugs, what antihypertensive drugs should be selected as the most reasonable? 1, combined with heart failure patients angiotensin converting enzyme inhibitors is one of the best choices. For heart failure patients with a tendency to swelling, a small dose of diuretic can be used in combination, preferably with double grams, which has a potassium excretion effect, which can exactly offset the side effect of potassium retention of angiotensin-converting enzyme inhibitors. However, it should be noted that angiotensin-converting enzyme inhibitors are contraindicated in patients with pregnancy, severe bilateral renal artery stenosis, and severe renal failure. Diuretics (long-term, high-dose) should be used with caution in patients with diabetes, gout, and hyperlipidemia. 2, combined myocardial infarction, angina pectoris patients β-blockers + angiotensin converting enzyme inhibitors is a good choice, however, β-blockers are prohibited in patients with asthma, atrioventricular block of degree II or higher, unstable severe heart failure. 3, simple systolic hypertension in the elderly Diuretics + long-acting dihydroarsenicals in combination can often achieve better results. 4, combined with diabetes angiotensin-converting enzyme inhibitors, dihydroarbitrates. Among them, angiotensin-converting enzyme inhibitors are preferred as long as the patient has no contraindications. The target value of blood pressure control is <130/80mmHg. 5, combined with prostatic hyperplasia α1 receptor blockers. Be alert to the occurrence of postural hypotension when applying, and ask the patient not to stand up too quickly or too sharply from a prone or squatting position. 6, acute stroke about the acute phase of stroke blood pressure control, advocate following the principle of caution, moderate. In the acute phase of cerebral hemorrhage, most of the apparently elevated blood pressure is due to stress reaction and increased intracranial pressure, dehydration and lowering of cranial pressure can often effectively lower blood pressure. can lead to a sharp decrease in cerebral blood flow and perfusion. Aggravate cerebral infarction, advocate the use of long-acting drugs to make a gentle, slow decline in blood pressure, maintain at a slightly higher level of normal. Regardless of the cause of renal damage, control of hypertension plays a key role in preventing the continued progression of renal lesions, and blood pressure should be controlled more strictly, with blood pressure <130/80 mmHg. Changes. It should be especially emphasized that drugs are only one important part of the treatment plan for hypertension. A good lifestyle, low salt and low fat diet, proper exercise, weight control, etc., are the cornerstones of controlling over hypertension and should never be neglected.