There is no fastest solution for bile duct blockage. Bile duct obstruction is caused by stones, tumors and other factors, and can be treated by puncture drainage and surgery. 1. Stones: bile duct obstruction caused by bile duct stones should be drained by bile duct or gallbladder puncture, and the stones should be removed by choledochotomy or endoscopic retrograde cholangiopancreatography. 2. Tumor: bile duct obstruction caused by biliary tumor should be treated according to the size, benign or malignant nature of the tumor, and generally surgery is adopted to remove the biliary tumor to relieve bile duct obstruction, such as pancreaticoduodenectomy, choledochotomy, etc. In addition, those with palliative treatment can be treated with choledochotomy or gallbladder puncture to drain the bile duct or gallbladder. In addition, for palliative treatment, endoscopic retrograde cholangiopancreatography biliary stent implantation or gallbladder puncture and drainage can be chosen. If bile duct blockage occurs, should promptly go to the hospital, improve the relevant examination to clarify the cause, standardized treatment under the guidance of the doctor, avoid unauthorized use of drugs or treatment.