Whether the pain in the cheeks can be cured when the mouth is opened depends on the cause of the pain, if it is caused by physiological reasons, such as muscle strain caused by chewing hard objects, it can be cured. If the pain is caused by temporomandibular joint disorder syndrome, inflammation of the parotid duct orifice, oral ulcers and other pathologic factors, it generally can not be self-healing, and should be promptly consulted to find out the cause of the disease. Physiological factors, such as muscle strain caused by chewing hard objects, generally do not need treatment, avoid eating too hard food, eat a light diet, rest for a few days can be self-healing. If you are suffering from TMJ disorder syndrome, joint soreness or pain is more obvious when you chew and open your mouth. If the onset of the disease is short and the symptoms are mild, it may heal on its own. However, if it lasts for a long time, develops to the stage of pain and there is a limitation of opening the mouth, jaw retraction, and a crooked face, it cannot be healed on its own, and requires surgical treatment. If the catheter port is infected and inflamed, or the catheter port is inflamed due to catheter obstruction, it will also lead to pain in the cheeks when opening the mouth, which cannot be cured by itself, and it is necessary to go to the hospital for the unblocking of the catheter port and anti-inflammation in order to relieve the pain. If the mouth ulcers caused by a mouth open cheek pain, light mouth ulcers generally 1 ~ 2 weeks since the healing, heavy mouth ulcers patients need to local topical medication or oral vitamin drugs, such as cotrimoxazole, rehabilitation of new liquid, vitamin B1, etc., usually a few weeks to 1 ~ 2 months ulcers can be healed. Therefore, there is a mouth open cheek pain in the exclusion of physiological factors, should be timely to the hospital, under the guidance of the doctor according to the cause of standardized treatment.