The causes of itching at the mouth of the sock include tinea pedis, atopic dermatitis, tight socks, scabies, etc. The treatment drugs include antifungal drugs, anti-inflammatory drugs, insecticides and so on. 1. Tinea pedis: If the itching at the mouth of the sock is caused by fungal infection, itraconazole, isoconazole and other medications can be given for antifungal treatment. 2. Allergic dermatitis: For patients with allergic dermatitis, it is necessary to replace the socks with new ones and apply dexamethasone cream at the same time. 3. Tight socks: If the skin is edematous due to tight socks, the symptoms can be relieved after taking off the socks. 4. Scabies: when the calf is infected by scabies, you can give 25% benzyl benzoate emulsion or sulfur ointment and other drugs anti-scabies treatment. Finally, the phenomenon of itching at the mouth of the socks, please go to the hospital in time to check, the above drugs need to follow the doctor’s advice.