Drinking alcohol should be avoided for 1-2 weeks after hepatitis B vaccination, especially avoiding heavy drinking to avoid affecting the effect of vaccination. Alcohol should not be consumed during hepatitis B vaccination, especially within 1-2 weeks after vaccination, to avoid affecting the immunization effect after vaccination. First of all, drinking alcohol may increase the sensitivity of the body, resulting in allergic reactions after hepatitis B vaccination. In addition, drinking alcohol may also damage the liver, especially in case of heavy drinking, which may lead to liver cell damage and decreased liver function, thus affecting the production of hepatitis B surface antibody. At the same time, alcohol consumption can also produce adverse reactions related to hepatitis B vaccination, such as fever, nausea, loss of appetite, etc. Therefore, alcohol consumption should be avoided as much as possible during hepatitis B vaccination. In addition, patients should avoid pressing and rubbing the site of hepatitis B vaccination, avoiding strenuous exercise, drinking alcohol, smoking, and avoiding drinking coffee and strong tea after vaccination, as well as paying attention to keeping a relaxed mood.