With the continuous progress of the society and the gradual improvement of people’s living standard, obesity, hypertension, diabetes mellitus and hyperlipidemia are further expanding, the existence of these risk factors will inevitably promote the development of atherosclerosis, which will lead to the involvement of arteries all over the body, thus triggering the well-known coronary heart disease, stroke, carotid stenosis, atherosclerotic occlusion of the lower limbs and other diseases. All of the above diseases are caused by the continuous occurrence and development of atherosclerosis, which leads to the narrowing or occlusion of the relevant blood vessels, and the most harmful ones to human beings are coronary heart disease and stroke. According to the 2015 statistics of the former National Health and Family Planning Commission, the death of cardiovascular diseases accounted for the first cause of death of major diseases, at the same time, the rejuvenation of coronary heart disease is also a serious threat to the health of human beings, and it has been reported that the age of onset of patients with coronary heart disease in China has been advanced by 10 years compared with that of the 1980s. For patients who have been clearly diagnosed with coronary heart disease, according to the severity of angina pectoris is divided into two categories: stable coronary heart disease and acute coronary syndrome. Coronary heart disease is treated with medication, interventional therapy and surgery. So, the blood vessel blockage must be put stents through interventional therapy? The answer is of course no. It depends on the severity of the patient’s blood vessel stenosis and the type of coronary artery disease. Patients with acute coronary syndrome, especially those with acute ST-segment elevation myocardial infarction, should open the blocked coronary artery as soon as possible to restore blood supply to the myocardium, to avoid sudden cardiac death and heart failure after extensive myocardial necrosis. It needs to be especially emphasized that “time is myocardium”, which means that the earlier the occluded vessel is opened, the more myocardium will survive, thus reducing the patient’s morbidity and mortality rate; patients with stable angina pectoris, according to the recommendations of the 2018 Chinese guidelines on the diagnosis and treatment of stable coronary artery disease, patients with ischemic symptoms despite intensive drug therapy and the If there is evidence of large-scale myocardial ischemia, and the benefit of stenting is predicted to be greater than the risk, interventional therapy for stent placement may be considered. Interventional therapy should be chosen for any coronary artery with a diameter stenosis of >70%, manifested by activity-induced angina or equivalent symptoms, and poor response to pharmacologic therapy. To summarize, for acute myocardial infarction has occurred, in the case of conditions permitting should be opened as soon as possible occluded vessels; for plaque stability of patients, can consider the systemic drug therapy, if drug therapy is ineffective and pre-determined that interventional therapy may benefit should also be selected for interventional therapy. Interventional therapy for coronary artery disease has evolved from simple coronary angiography, simple balloon dilatation, bare metal stenting, and drug-eluting stenting to the current drug balloon dilatation, bioabsorbable stenting, and the clinical application of 3D printing technology. Drug-eluting stenting is still the most commonly used in clinical practice, while drug-eluting balloons can be used in some patients with post-stent restenosis, small vessel lesions, bifurcation lesions, and patients with a high risk of bleeding. At present, cardiovascular interventional therapy is widely developed, and the level of interventionalists and interventional devices have made great progress compared with the past, therefore, for patients suitable for interventional therapy, the choice of interventional therapy can reduce the mortality rate of patients and prolong the life expectancy. Of course, for patients whose stenosis is not yet at a level that requires stenting, stenting should not be chosen blindly. Choosing the appropriate procedure will maximize the benefit to the patient.