Pancreatitis can cause blood in the stool, but it is relatively rare in clinical practice. Acute simple edematous pancreatitis does not cause blood in the stool, but hemorrhagic necrotizing pancreatitis, which is often referred to as severe pancreatitis. The reason for the blood in the stool, on the one hand, may be the severe pancreatitis body stress state, so that the digestive tract stress ulcers, resulting in blood in the stool. In the case of upper gastrointestinal bleeding, such as gastric and duodenal bleeding, there is even the possibility of vomiting blood. On the other hand, pancreatic fluid is activated in the abdominal cavity, corroding blood vessels as well as intestinal tubes, resulting in intra-abdominal hemorrhage and intestinal fistulae, which may also cause blood in the stool. When blood in the stool occurs, the cause of the bleeding should be investigated promptly. On the basis of rapid blood transfusion, fluid transfusion and application of hemostatic drugs, bleeding can also be stopped by embolization of the bleeding vessels through interventional angiography, and in severe cases, surgery may be required.