There are some people in life who have to undergo craniotomy because they suffer from some kind of craniocerebral disease or because of an accident. After craniotomy, some sequelae are also prone to occur, for example, some patients after craniotomy surgery appeared skull damage, which also need to pay attention to. After all, the skull is responsible for protecting the intracranial tissues, once the cranial bone defects are very big, so it is necessary to do cranial bone repair surgery. This is mainly according to the actual situation of the patient to determine, the current neurosurgery advocate early or ultra-early cranial repair, generally speaking, 3 months after the defect is the more ideal time for surgery. And before doing the cranial bone repair surgery, must make sure that the patient’s intracranial no other abnormalities occur. Nowadays, some hospitals are using titanium mesh for skull repair. Titanium mesh material does have some progress compared to the traditional material in the past, but it inevitably has some problems, such as postoperative infections or rejection, collapse and deformation, exposure of the material, etc., so we don’t advocate the use of it anymore. To achieve better results in cranial bone repair surgery, a more secure and advanced repair material is needed, and the new polyether ether ketone peek material is very good. peek material’s properties are very compatible with the autologous skull, and it avoids the shortcomings of the traditional materials, and the postoperative recovery is very ideal. Of course, not all hospitals are able to use peek material for surgery, and patients need to carefully choose experienced and skilled hospital doctors to do it.