Adapalene and tazarotene are two drugs with completely different components, each with its own pharmacological action. Adapalene is a retinoid compound that has been shown to have anti-inflammatory properties in vivo and in vitro in inflammatory conditions. Adapalene inhibits the chemotactic response of human polymorphonuclear leukocytes and inhibits the conversion of arachidonic acid into inflammatory mediators via lipid oxidation reactions. Human clinical trials have also shown adapalene, to alleviate the inflammatory response to seizures. Tazarotene is a third-generation retinoic acid that regulates keratin-forming cell differentiation, anti-proliferation and anti-inflammation. Tazarotene cream in combination with glucocorticoids for the treatment of psoriasis can increase the efficacy of glucocorticoids. When using it, you need to choose according to your condition and choose the right drug for your treatment from a practical point of view.