Abdominal pain may be caused by acute gastroenteritis, acute appendicitis and other diseases, no relief of abdominal pain after infusion indicates that the treatment effect is not good, it may also be caused by drug allergies, need to take medication, surgical treatment for the specific causes. Clinically, there are many causes of abdominal pain, most commonly seen in acute gastroenteritis, acute appendicitis and other diseases. If the abdominal pain is not relieved after infusion, it is mostly considered that the drug is not effective, and may need to be replaced, combined with drugs, or surgical treatment. However, abdominal pain may also be caused by drug allergy, and appropriate treatment measures need to be taken according to the specific situation. For acute gastroenteritis, patients need to apply probiotics such as Bifidobacterium bifidum and Saccharomyces boulardii, as well as anticholinergics such as scopolamine and atropine, as prescribed by the doctor. If bacterial infection is present, antibiotics such as norfloxacin and ciprofloxacin are prescribed. For acute appendicitis, patients need to apply cephalosporin antibiotics, such as cefradine and ceftriaxone, as prescribed by the doctor. At the same time, need to combine the application of metronidazole, if the effect of drug treatment is not good, then need to consider laparoscopic surgery, open surgery and other manual treatment. For drug allergy, patients need to follow the doctor’s instructions to apply cetirizine, phenylephrine and other antihistamines, as well as methylprednisolone, prednisone and other glucocorticosteroids, as well as vitamin C, calcium gluconate and other drugs, which can reduce capillary permeability and relieve discomfort. There are more reasons for the lack of relief of abdominal pain after infusion, and it is necessary to report to the doctor in time to adjust the treatment program so as not to delay the condition. The drugs all need to be used in accordance with the doctor’s instructions.