Heart failure can not be stopped even after the heart failure is well Nosinitor® (sacubitril valsartan), heart failure symptoms are relieved, but the problem of cardiac remodeling still exists, you need to follow the doctor’s advice to adhere to the medication. 1. Sacubitril valsartan is an enkephalinase angiotensin receptor inhibitor, which works by antagonizing the renin-angiotensin-aldosterone system, inhibiting vasoconstriction, improving cardiac remodeling, and improving long-term survival in heart failure. Therefore, even if the patient’s heart failure symptoms are completely resolved, the drugs that still have to be taken include enkephalinase angiotensin receptor inhibitors. 2. Sacubitril valsartan is contraindicated in people who are allergic to it, angioedema associated with angiotensinase inhibitors and receptor inhibitors, hereditary or idiopathic angioedema, and is prohibited in combination with angiotensinase inhibitors. Adverse reactions include angioedema, hypotension, renal impairment, hyperkalemia. 3. In addition, if there are no contraindications, the drugs that need to be taken for a long period of time for heart failure include beta-blockers, such as metoprolol and bisoprolol. This is because beta-blockers, like enkephalinase angiotensin receptor inhibitors, are drugs that improve prognosis and reduce hospitalization and death rates in heart failure. Please consult with your hospital doctor for specific dosage and cycle, and apply under the doctor’s supervision.