Epilepsy is caused by abnormal discharge of neurons in the brain causing sudden general convulsions, tightening of limbs, foaming at the mouth, often accompanied by screaming, etc. But what causes abnormal discharge of neurons in the brain, primary is not clear why, secondary causes are many, no matter what the cause, need to be actively treated, because the recurrent seizures, the impact on the physical and mental health of patients, the uncertainty of the seizure threatens the life of the patient. In the treatment, many people will first ask drugs, because drugs for the conventional treatment of the disease, then the treatment of epilepsy drugs which? The actual fact is that there are many clinical drugs for the treatment of epilepsy, such as sodium valproate, carbamazepine, phenytoin sodium, clonazepam, lamotrigine, oxcarbazepine, levetiracetam, gabapentin, etc., which have certain effects on the treatment of epilepsy, but of course, western drugs also have side effects and contraindications. The actual fact is that you can find out more about the actual situation of the patient. The patient is advised to take the medication under the guidance of a professional doctor for long-term effectiveness and less seizures. If many anti-epileptic drugs have been tried with poor results, surgical treatment may be considered. In the past, surgical treatment was mostly focal resection, but this procedure is not suitable for every patient and has certain surgical indications and risks. If the patient is not suitable for surgery, there is no choice but to continue to take medication, and the effect of medication is not good, there are many such patients and they are very helpless. Now, with the advancement of technology, there is a way to treat patients with intractable epilepsy who are not suitable for surgery and whose medication is not effective, and our department carries out neuromodulation therapy, specifically “vagus nerve stimulation (VNS)”, which is a method to treat epilepsy through neuromodulation without opening the skull. It changes the previous treatment mode of craniotomy to remove the lesion. This method plays an active role in the treatment of refractory epilepsy that cannot be controlled by drugs. It improves the firing pattern of the brain by stimulating the vagus nerve on the left side of the body to play a role in controlling seizures. Vagus nerve stimulation reduces the frequency and number of seizures, the duration and severity of seizures in patients. As well as improving the patient’s postoperative quality of life and cognitive ability. The overall efficiency of VNS is comparable to that of craniotomy, about 70%, and the rest of patients have different degrees of reduction. The overall efficiency of VNS is comparable to that of craniotomy, with about 70% of patients having varying degrees of reduction. However, compared with craniotomy, VNS is relatively less invasive and the procedure is simpler and more easily accepted by the majority of patients. To date, more than 80,000 patients have been treated with vagus nerve stimulation in 75 countries worldwide. Vagus nerve stimulation is recognized worldwide as the newest and most effective treatment for intractable epilepsy.