Refractory epilepsy is a syndrome of central nervous system malfunction caused by highly synchronized abnormal discharges of neurons in the brain caused by different etiologies, and dominated by limb convulsions and sensory disturbances. Currently, drug therapy is effective in 90% of epilepsy patients, but there are still 10% of patients for whom antiepileptic drugs are ineffective and seizures are difficult to control, which is called refractory epilepsy. For refractory epilepsy, the department uses “stereotactic electroencephalography (SEEG) technology to precisely locate the epileptic foci, and then minimally invasive surgery to cure epilepsy. . The main advantages of this technique are: 1. Precise localization: each patient has an individualized surgical path, and the electrode contacts can capture the epileptic foci; 2. Less invasive surgery: only small holes of about 2 mm need to be drilled in the skull under local anesthesia; 3. Monitoring of deep brain neural structures: the hippocampus, internal olfactory area, cingulate gyrus, insula, and cortical dysplasia can be monitored; 4. Comprehensive function: in addition to checking the epileptic foci, it can also 5.Thermal coagulation destruction function: For epileptic lesions, the thermal coagulation function of electrodes can be used to destroy them, avoiding craniotomy. The above-mentioned SEEG radiofrequency thermocoagulation can significantly reduce the seizure frequency or even achieve seizure-free. sEEG-guided radiofrequency thermocoagulation has the following advantages: 1. the number of implanted electrodes allows flexible selection of the destruction area and treatment of multifocal epilepsy; 2. real-time EEG monitoring before, during and after surgery can be realized; 3. possible complications after thermocoagulation destruction can be predicted; 4. some Some of the disruptions do not require anesthesia and are well tolerated by patients; 5. The operation is easy and less traumatic; and the operation time is short, with one electrode disruption completed in a few minutes; 6. This localization surgery technique is suitable for: seizures with whole brain discharge, cortical dysplasia, tuberous sclerosis, hypothalamic malformation tumor, gray matter ectopic, medial temporal lobe epilepsy and other intractable epilepsy. Experts believe that this minimally invasive technique has been widely used in Europe and the United States, and with the gradual popularization of its clinical application in China, it will benefit more patients with intractable epilepsy.