Oral medications to stop itching, including antihistamines, allergic reaction mediator blockers, tricyclic antidepressants, etc., due to personal constitution and different conditions, there is no such thing as the best oral medication to stop itching. 1. Antihistamines: antihistamines such as promethazine, phenylephrine, cetirizine, loratadine, etc. have the effect of resisting itching, and their common adverse reactions include drowsiness, fatigue, and weakness. 2. Allergic reaction mediator blocker: such as ketotifen, montelukast and other drugs. Common adverse reactions include loss of appetite, weight gain, drowsiness, dizziness and so on. 3. Tricyclic antidepressants: tricyclic antidepressants such as doxepin and amitriptyline can control itching, with adverse reactions such as excessive sweating and dry mouth. The use of drugs should be under the guidance of medical professionals to avoid adverse reactions.