The reason why hands wrinkle without soaking in water for a few minutes is usually due to the change in osmotic pressure of the hands in water, which is a normal phenomenon. When the hands are soaked in water, water molecules can penetrate through the cell membrane to the skin between the surface layer and the dermis, the dermis usually does not absorb water to expand, but the surface layer of the skin may absorb water to expand, which leads to changes between the surface layer and the dermis, the appearance of the hands in the water within a few minutes of soaking wrinkled phenomenon. In addition, when the hand is placed in the water for a long time, the surface layer of the skin will absorb a lot of water, eventually leading to some of the cells swollen and denatured, which is also one of the reasons why the finger soaking wrinkles.