Gentian herb has the effects of clearing heat and drying dampness (removing heat and drying dampness) and diarrhea of liver and gallbladder fire, and can be replaced by herbs with similar functions, commonly such as bitter ginseng and cypress. Gentian herb can be used clinically to treat yellowish odor under the belt, swollen and itchy yin, eczema and itchy eczema caused by damp-heat in the lower Jiao (dampness and heat invading the intestines, bladder, yin and lower limbs), as well as for treating redness and swelling in the eyes and pain in the mouth caused by liver and gallbladder fire, and coercive pain and bitterness in the mouth (pain in the coercive area and bitterness in the mouth). The efficacy of gentian herb in clearing damp-heat in the lower Jiao is better, and it can be replaced by bitter ginseng or cypress in clinical practice. Bitter ginseng has the effect of clearing heat and drying dampness, and its bitter and cold power is stronger than that of gentian herb, which also has the effect of killing worms and diuretic. In addition, we can also use cypress to replace gentian herb, cypress can also play a clearing of dampness and heat in the lower Jiao, diarrhea and detoxification (to remove the body’s fire, poison and evil) effect. Gentian herb is bitter and cold in nature, which may cause stomach pain, loose stools and other adverse reactions, and is contraindicated in people with cold spleen and stomach (weak and cold spleen and stomach). Gentian herb should be used correctly under the guidance of a professional Chinese medicine practitioner, do not take the medicine blindly to avoid adverse reactions.