Ozone injections are generally not harmful when administered in a reasonable manner and in accordance with medical advice, but if administered unreasonably over a long period of time, they may cause localized muscle spasms, joint stenosis, and even dependence. Ozone injections can be used to treat conditions such as arthritis or joint cavity lesions, and to improve the environment in the joint cavity to relieve discomfort. If you take ozone injection once or twice in a while, it will not cause any side effects to your body. However, long-term ozone injections may cause localized muscle spasms, damage, or narrowing of the joints, which may affect the later effects. In addition, a certain degree of dependence can be created if ozone injections are administered for a long period of time. When choosing ozone injection treatment, you should see if surgical treatment is required. Proper exercise is recommended after ozone injection, and rest is also needed to avoid overwork.