Hepatitis B virus 4 of 10 usually takes 3 to 6 months to come down, but it is still necessary to continue taking medication after the viral titer comes down. Hepatitis B virus 4 times 10 indicates that the patient’s body has a moderate amount of replication of the hepatitis B virus, and can be treated by injecting interferon or taking antiviral medication. If interferon is used to treat hepatitis B, the quantification of the hepatitis B virus can be carried out again after 3 months of treatment, and at this time, if the viral quantification is reduced to 2 times 10, then it means that the treatment is effective. For patients taking antiviral drugs such as entecavir, tenofovir and propofol tenofovir for the treatment of hepatitis B, if the hepatitis B virus becomes negative when the virus quantification test is conducted again 3-6 months after the treatment, it also indicates that the treatment is effective. It is still necessary to continue the treatment after the virus has turned negative in order to avoid a rebound of the disease. During the period of medication, the virus may develop drug resistance, liver function abnormalities, etc. Please consult your doctor in time and follow the doctor’s instructions to complete the treatment.