Currently, SLE is not completely curable, but with systematic and standardized treatment most patients can achieve long-term remission and can have the ability to live and work normally. SLE is a chronic autoimmune disease with multi-system and multi-organ damage, which is essentially a pathological reaction caused by the autoimmune system attacking its own cellular organs. Abnormal immune inflammation is the pathological feature of SLE. Genetics, infection, and estrogen are related to the occurrence of SLE, but the specific etiology and pathogenesis are still unclear, so there is a lack of curative drugs. Adrenocorticotropic hormones plus immunosuppressive agents to regulate the immune response are the main treatment options to slow down the progression of the disease, reduce complications and protect the function of important organs. Failure to cure is by no means equal to failure to control the progression of the disease. With the improvement of medical level and the development of a large number of new drugs, under systematic and standardized treatment, most patients can be in long-term stability and remission, and the prognosis and survival rate of SLE patients have been significantly improved compared with those in the past, and patients can work and live like normal people. Although SLE cannot be completely cured, it can be controlled. Early diagnosis, systematic and standardized treatment are the keys for SLE patients to keep their disease stable, and they also need to maintain a good and healthy state of mind and establish self-confidence in treatment.