Swelling of the fingers in the morning needs to be judged according to the actual situation. If swelling occurs in one hand, it may be caused by local lesions, such as mosquito bites, allergies, or sleeping on the side of the upper limb, and the upper limb needs to be compressed, which needs to be analyzed accordingly. If both hands are swollen, systemic lesions may play a leading role. In women, menstrual edema, or edema caused by drinking too much water before bedtime, may be present. Excluding these causes, the most common are systemic lesions, such as cardiac lesions, renal lesions, etc. Rheumatoid arthritis and osteoarthritis in rheumatologic systemic lesions are also more common. Cardiac lesions often have a history of heart disease, and if there is a feeling of swelling in the fingers in the morning, it means that there may be symptoms of heart failure, and an electrocardiogram and cardiac ultrasound can help in the differential diagnosis. Swelling of the hands in kidney disease indicates that the kidney disease may be more serious and requires further urine and blood imaging for differential diagnosis. Rheumatoid arthritis, one of the systemic diseases, can present with swelling of the hands, accompanied by stiffness of the finger joints, which is relieved by movement, and the appropriate blood tests may suggest some useful diagnostic information.