In the treatment of chronic hepatitis B M C process more or less will appear some adverse reactions, some are mild, transient, do not have to stop the drug, but some are more serious, must stop the drug, now the treatment of common adverse reactions and treatment for an introduction. 1, fever: usually seen in the first three injections of interferon. Almost all treatment patients about 2-4 hours after the first injection are transient hyperthermia, body temperature up to 38-39 degrees, 4-6 hours later often without treatment natural decline, the second, the third injection after the gradual reduction or disappear. ? 2.Flu-like syndrome: Mostly appear 2-4 hours after injection. There are fever, chills, malaise, liver pain, back pain and digestive symptoms, such as nausea, loss of appetite, diarrhea and vomiting. It gradually decreases after 2-3 times of treatment. For cold-like syndrome, antipyretic and analgesic agents such as paracetamol can be given 2 hours after the injection and treated symptomatically without stopping the drug; or schedule the injection at night. 3. Bone marrow suppression: Leukocyte and platelet reduction occurs, which can generally recover on its own after stopping the drug. If leukocytes and platelets continue to drop during treatment, closely observe the changes in blood picture. When the white blood cell count <3.0×10^9/L or neutrophil count <1.5×10^9/L, or platelet count <40×10^9/L, the drug should be discontinued, closely observed and treated symptomatically, and attention should be paid to bleeding tendency. Treatment can be resumed after the blood count recovers. However, close observation is required. 4, neurological symptoms: such as insomnia, anxiety, depression, excitement, irritability, psychosis. Depression and psychotic symptoms should be discontinued. 5. Rare side effects: such as epilepsy, nephrotic syndrome, interstitial pneumonia and cardiac arrhythmia. When these diseases and symptoms appear, the drug should be discontinued for observation. 6. Induced autoimmune diseases: such as thyroiditis, thrombocytopenic purpura, hemolytic anemia, rheumatoid arthritis, lupus erythematosus-like syndrome, vasculitis syndrome and type I diabetes mellitus.