Toothpaste only has the function of cleaning your teeth and cannot remove dark spots on your face. To remove dark spots on the face, you can try to strengthen sun protection measures, medication, medical treatment and other methods. 1. Strengthening sun protection measures: excessive exposure to ultraviolet rays will aggravate dark spots on the face and lead to different degrees of hyperpigmentation on the face. Therefore, in order to remove dark spots on face, patients should pay attention to strengthening sun protection measures, such as using hats, masks, umbrellas, sunglasses, sunscreen, sunscreen sprays and other sunscreen products when going out, which can help to isolate the damage of ultraviolet rays on our skin. 2. Medication: For patients with mild dark spots on face, they can use 2%-5% hydroquinone cream, 4% tretinoin, 15%-20% azelaic acid cream, compound arbutin cream and other ointments to apply locally, which can help to lighten the dark spots and brighten the skin color; for patients with serious dark spots on face, they can take vitamin C, vitamin E, tranexamic acid and other medicines to help to improve the dark spots better. 3. Medical aesthetic treatment: For patients whose appearance is greatly affected by dark spots on face, they can try to use laser treatment, photorejuvenation, chemical peeling and other medical aesthetic treatments to help remove dark spots on face, which have better effect. It should be noted that the above treatments should be carried out under the guidance of physicians to avoid the occurrence of adverse reactions.