Tooth pain resulting in half of the face is swollen and fever, may be periodontitis, apical periodontitis, wisdom tooth pericoronitis, can be relieved through general treatment, physical therapy, drug treatment, surgical treatment and other measures. 1. Periodontitis: Periodontitis, especially the formation of periodontal abscess may lead to half of the face is swollen, you can choose to incise and drain the pus, local application of minocycline, oral metronidazole and other drugs for anti-inflammatory, but also need to carry out systemic periodontal therapy. 2. Periapical inflammation: thorough root canal treatment is needed, and several changes of medication are required during the treatment to eliminate the inflammation in the periapical area. 3. Wisdom tooth peri-coronitis: acute stage of wisdom tooth peri-coronitis can be carried out using saline, hydrogen peroxide for peri-coronary rinsing, oral metronidazole, cephalosporin can control the infection, to be eliminated after the elimination of inflammation to consider the removal of wisdom teeth. Tooth pain caused by half of the face are swollen, it is recommended to go to the hospital for examination, treatment as prescribed by the doctor, the use of drugs need to comply with medical advice.