There are many types of antibiotics, better than cephalosporin, including meropenem, imipenem, vancomycin, teicoplanin, tigecycline and so on. However, in general, cephalosporin antibiotics are used more often, and cephalosporin antibiotics also target different bacteria and have different requirements, there are generation one cephalosporin, generation two cephalosporin, generation three cephalosporin and generation four cephalosporin, whose antibacterial spectrum is different. First- and second-generation cephalosporins are mainly for Gram-positive cocci and bacilli; third- and fourth-generation cephalosporins are mainly for Gram-negative bacilli and also have anti-infective effects on cocci. Therefore, if it is an abdominal lesion, such as appendicitis or cholecystitis, generally more second-generation cephalosporins or third-generation cephalosporins are used for treatment, and only refractory abdominal infections are considered to be treated with particularly good antibiotics.