Leukemia is more serious compared with SLE. 1. Leukemia is a malignant tumor of the blood system with a critical condition, especially acute leukemia, which progresses more rapidly. If leukemia patients are not treated in time, their lives can be endangered in a short period of time due to severe bleeding, anemia and infection. The prognosis for most leukemia patients is not very good. Therapeutic drugs include cytarabine and Zoerythromycin. 2. SLE is an autoimmune disease. Skin-type lupus erythematosus has mild symptoms, mainly manifested as butterfly-shaped erythema of the skin, discoidal erythema, and in severe cases, there is alopecia, accompanied by swelling and pain in the muscles and joints, but it generally does not affect the patient’s natural life span. When the disease is serious or the treatment is not standardized, it is easy to lead to the functional impairment of tissues and organs, endangering patients’ lives. Treatment drugs include prednisone, etc. It is worth noting that, whether it is leukemia or SLE, once diagnosed, it is necessary to actively regulate the treatment under the guidance of physicians.