Babies who are positive for Mycoplasma pneumoniae need to be treated with oral azithromycin and nebulization. Mycoplasma pneumoniae is a microorganism between bacteria and viruses with no cell wall structure. Mycoplasma pneumoniae is a common type of pneumonia in school-age children, manifested by fever, persistent and severe cough mainly at night, and wheezing and respiratory distress may occur in infants and young children. Mycoplasma pneumoniae infection preferred macrolide antibiotics, such as azithromycin, can inhibit bacterial protein synthesis, preventing the composition of ribosomal subunits, pay attention to follow the doctor’s instructions to use enough course of treatment. When the baby has asthma, dyspnea, can be given glucocorticoid nebulization therapy, reduce inflammation exudation, release bronchospasm. The above drugs need to be used under the guidance of a physician, and should not be used on their own to avoid danger.