Different kidney diseases cause different causes of leg acidity, the common causes of leg acidity are edema, nerve injury, metabolic acidosis and so on. 1. Edema: Patients with kidney disease may have large amount of proteinuria and edema, which can be manifested as leg soreness in the lower limbs. 2. Nerve damage: patients with kidney disease may have toxins that can not be completely discharged from the body, toxic and harmful toxins accumulate for a long time, which can lead to peripheral nerve damage, patients may have numbness in both lower limbs, and at the same time, they may combine with the situation of leg acidity. 3. Metabolic acidosis: chronic renal failure can lead to weakening of the kidney’s function of removing acid and other toxins. Acid can not be excreted in time, and it is easy to accumulate in the body, which can cause metabolic acidosis and lead to generalized acidity, including the legs. It is recommended to go to the regular hospital for examination to find out whether it is caused by kidney disease, and then according to the specific cause of the disease, carry out targeted treatment.