The nasolabial fold is an anatomical structure that is located at the junction of the nose and cheeks. How is it formed? The first thing to say is that biomedical genetics, every human being, including some other advanced animals, has a set of genes that determine, in itself, the formation, that is one. Secondly, it is important to know that the face is completely different from the alignment of its muscles and the alignment of the muscles on both sides of the nose. The external nose bulges, and the muscles of the face are shaped downward and outward, which is the direction of the different alignment of the muscles, forming a different shallow concave groove at the turn of the nose and face, then this is the nasolabial folds. In short, its formation is due to biological genetic decision, and the second one is due to its own anatomical structure needs.