Pimples are very red, very big and very hard and hurt when pressed. This symptom is commonly seen in folliculitis or acne, which are treated differently according to different causes, usually through medication. Folliculitis is an inflammation of the surface of the skin by bacterial infection; acne is due to the high secretion of oil, the mouth of the hair follicle is blocked, and bacteria multiply in the hair follicle, resulting in inflammation. 1. Folliculitis: depending on the infectious agent, antibiotics or antifungal medications should be chosen. If the symptoms are mild, topical drugs can be used, such as clindamycin gel, etc.; if the symptoms are severe, oral drugs will be chosen for anti-infection treatment, such as doxycycline. If necessary, a combination of drugs will be used. 2. Acne: mild symptoms, local topical creams or lotions for treatment, such as benzoyl peroxide gel, etc.; mild to moderate symptoms, take topical retinoic acid drugs for treatment, such as tazarotene, adapalene gel, etc.; moderate symptoms, you can choose antibiotic drugs for treatment, such as fusidic acid cream, etc.; symptoms of seriousness, you can oral treatment of isotretinoin drugs, such as isotretinoin soft capsules and so on. If the pimples are very red, very big and very hard, it hurts when pressed, you should consult the doctor in time, and standardize the use of medication after clarifying the cause of the disease.