There are several reasons for the face to become bigger, there are physiological obesity, and pathological reasons. Physiological obesity, such as weight more than twenty pounds in a month will therefore lead to a larger face. If it is not physiological obesity but pathological factors, the most common is endocrine diseases. Endocrine diseases can cause the face to become bigger as follows: a. Cushing’s syndrome, manifested as centripetal obesity, typical full-moon face, buffalo back, that is, the face is abnormally large, accompanied by purple skin lines, sweaty hair, etc., blood test and cortisol can be clearly diagnosed. Second, acute hyperadrenalism will also have sudden face enlargement and other symptoms. Hypothyroidism, commonly known as hypothyroidism, can be accompanied by mucinous edema, which can cause facial edema and make the face appear larger due to edema. Fourth, people with polycystic ovary syndrome will also have symptoms such as obesity, hirsutism, a larger face, and abnormal roughness of the facial skin.