H. pylori is a chronic source of infection and children infected with H. pylori suffer from associated diseases mainly chronic active gastritis, duodenal ulcers and gastric ulcers. Symptoms include abdominal pain, fullness, early satiety, anorexia or upper gastrointestinal bleeding. I. Combination therapy program for the eradication of pediatric H. pylori: 1. Bismuth-based program: bismuth plus 2 antibiotics: the more commonly used triple therapy in China is bismuth + amoxicillin (hydroxybenzyl penicillin) + metronidazole, a course of 2 weeks. Antibiotics can be chosen: amoxicillin (hydroxybenzyl penicillin), clarithromycin, metronidazole, tinidazole, tadronidazole, furazolidone. 2.Proton pump inhibitor (PPI)-based regimen: proton pump inhibitor plus 2 antibiotics. Commonly used method: proton pump inhibitor + amoxicillin (hydroxybenzyl penicillin) + clarithromycin for 2 weeks or 1 week. 3, H2 receptor blocker-based regimen: cimetidine and ranitidine or famotidine plus two antibiotics. Second, drug treatment can choose antibiotics Amoxicillin (hydroxybenzyl penicillin) 50mg/(kg?d) in 2 to 3 times. Tinidazole 20mg/(kg?d), divided into 2 to 3 times. Metronidazole 20mg/(kg?d) in 2 to 3 doses. Clarithromycin 15mg/(kg?d) in 2 times. Bismuth can be chosen: bismuth potassium citrate (colloidal bismuth subcitrate) 7～8mg/(kg?d). Bismuth salicylate. A proton pump inhibitor can be chosen: omeprazole 1mg/(kg?d) in 2 doses. For children who have been diagnosed with H. pylori choose whether drug treatment needs to be carefully decided, and the choice of treatment also needs to be decided by a professional gastroenterologist, must be used improperly is very easy to appear drug resistance.