Brucellosis is the most common bacterial zoonotic disease in the world, with more than 500,000 patients worldwide each year and 1-2 million new cases each year, with an incidence rate of more than 10/100,000 people in some countries and regions, and is an important public health problem in these regions. China’s human brucellosis in recent years is a significant upward trend, and from pastoral areas to non-pastoral areas. Brucella belongs to gram-negative, parthenogenic intracellular parasitic bacteria, very pathogenic, acute symptoms, can lead to granulomatous lesions in various organ systems throughout the body, easy to change to chronic, high recurrence rate, the human body is harmful, can cause disability and affect the ability to work. According to its clinical characteristics, it belongs to the category of “dampness and warmth”, “paralysis” and “deficiency loss” in Chinese medicine. In Western medicine, there are acute (within 3 months), subacute (3 months to 1 year), and chronic (more than 1 year) phases. Because of the intracellular parasitic characteristics of Brucella, antibacterial treatment requires the application of drugs that can enter the cells, and the efficacy of various antimicrobials alone is poor, and requires a combination of drugs and a longer course of treatment. The recommended antimicrobial regimen includes tetracyclines and rifampin or aminoglycosides, or doxycycline or minocycline alone (or a combination of doxycycline and cotrimoxazole, or a quinolone combined with rifampin, for a recommended 6-week course of treatment, generally requiring 2-3 courses. In vitro drug sensitivity tests suggest that the resistance rate of Brucella to the above antibacterial drugs is not high, and there are new drugs such as tigecycline (TIG) and other optional drugs on the market, but the treatment of brucellosis still has the problems of chronicity and recurrent attacks. The timely cure of acute brucellosis patients and the prevention of chronicity and recurrence are important issues of great concern to the medical community at home and abroad. Chinese medicine believes that the cause of brucellosis is dampness, there are damp heat, damp poison, cold damp, etc., but also some people put forward the “mixed gas for the disease” point of view. The pathogenic mechanism is damp-heat poisonous evil through the mouth or skin meridians outside the offending muscle surface, invade the middle jiao, ambush in the membrane original, gradually into the blood, injury to the liver and spleen, damage to the whole body. Dampness and heat infiltration, loss of surface defense, fever and sweating, evil stagnation of the meridians, obstruction of blood flow, painful wandering joints, and enlargement of the liver and spleen. If the heat prevails, Yin is depleted and the body is hot and thirsty; if the dampness prevails, Qi is obstructed, headache and body weight, muscles and joints are sore. If the disease is prolonged, the vital energy is depleted, the qi and blood are blocked, and the veins are stagnant, then the heart is troubled and sleepless, the joints are painful, and the tendons and veins are constricted. The disease is treated with antibiotics with exact effect, but it is easy to be chronic and recurrent, which brings great pain to patients. Our hospital adopts a combination of Chinese and Western medicine to treat the disease, which has achieved good results, and also reminds people to pay attention to unexplained persistent fever, they should definitely pay attention to the examination of this disease.