Swelling of neck and chin after radiotherapy for nasopharyngeal cancer may be due to occlusion of lymphatic vessels and capillaries in the neck, or radioactive dermatitis and patients being infected, etc. It can be treated by general treatment, local hot compress physiotherapy and drug treatment. After radiotherapy, nasopharyngeal cancer patients may suffer from occlusion of lymphatic vessels and capillaries in the neck, which leads to obstruction of fluid reflux in the head and neck, accumulation of fluid in subcutaneous tissues of the neck, and ultimately swelling of the neck and chin, in which case they can be treated with appropriate exercise and local hot compress physiotherapy to promote blood circulation, thus alleviating the swelling of the face and neck. Patients in the radiotherapy resistance will be lower, this time easy to trigger bacterial infection, may also lead to neck and jaw swelling, this time should be prescribed to take antibacterial drugs for treatment, such as amoxicillin capsules and roxithromycin and other treatments, in order to eliminate the swelling. In case of radiation dermatitis, glucocorticoid cream can be used under medical advice for treatment. Swelling of neck and chin after radiotherapy for nasopharyngeal cancer may also be the case of lymph node metastasis in the neck, in which case, one should consult doctor immediately, and should not use medicine blindly on one’s own, so as to avoid delaying treatment.