What are the signs of resistance to a nucleoside drug? The early stage of drug resistance can not feel any manifestations, if not treated in time may lead to liver function abnormalities, and in severe cases, liver failure may occur. Many patients have to do a drug resistance gene test, what is the significance and purpose of this test? Slow hepatitis B taking nucleoside analog antiviral therapy, based on previous studies, primary resistance is extremely rare, so usually do not do HBVDNA resistance test before taking. How long after taking the nucleoside analogs will I need to be tested for resistance genes? After taking nucleoside analogs, patients need to do relevant tests every 3-6 months, these tests include at least HBVDNA quantification, liver function, kidney function (depending on the type of drug taken), AFP and ultrasound (depending on whether there is cirrhosis of the liver choose to check once every 3-6 months), once found that the HBVDNA abnormally elevated during the course of taking drugs need to do the relevant drug resistance test, the existing test methods have been Existing testing methods can detect drug resistance strains of different drugs at one time, and the doctor can guide the patient to adjust the treatment program according to the results after obtaining the relevant results. If a patient does not have a timely review, is it possible that he or she is already resistant to the drug but does not know it? Drug resistance occurs within a certain period of time the patient does not feel, so patients with chronic hepatitis B taking nucleoside analog antiviral therapy should remember to follow the doctor’s instructions for regular review.