The most important diagnosis of primary sclerosing cholangitis is transendoscopic retrograde cholangiopancreatography, as well as magnetic resonance, ultrasound, and serum biochemistry. 1. Endoscopic retrograde cholangiopancreatography: this is the gold standard for diagnosis of the disease, through the examination, it can be found that there are annular stenosis inside and outside of the liver, the wall of the bile ducts is relatively stiff, the dilatation of bile ducts at the upper part of the stenosis is like a string of beads, and there is a “withered dendritic” change in the case of extensive involvement of the bile ducts in the liver. 2. Magnetic resonance cholangiopancreatic imaging: This is the preferred method because of its non-invasive nature. The intrahepatic bile ducts are discontinuous in many places and the extrahepatic bile ducts are uneven in thickness. 3. Abdominal ultrasound: thickening of the gallbladder wall, cholestasis, and thickening of the wall of the common bile duct. 4. Serum biochemistry: there is elevation of alkaline phosphatase, and elevation of ghrelin and ghrelin aminotransferase. If symptoms related to primary sclerosing cholangitis appear, it is recommended to consult a doctor for examination and active treatment under the guidance of a doctor.