Low back pain may be caused by cancerous diseases such as kidney cancer, lumbar malignant tumor, or non-cancerous factors such as lumbar strain, ankylosing spondylitis, etc. It is not possible to judge the disease purely based on the symptoms of low back pain, and it is recommended that the patient performs further differential diagnosis. Low back pain is a common clinical manifestation, and cancerous factors can cause low back pain. For example, kidney cancer can manifest as unilateral low back pain, accompanied by hematuria, abdominal mass and other symptoms. In addition, malignant tumor of lumbar spine may manifest as gradually aggravating low back pain, which is intermittent and aggravated after exertion, and radiating pain may appear if it presses the nerves, and may be accompanied by pathological fracture and local lumps. However, some non-cancer factors can also lead to low back pain, such as lumbar muscle strain, which manifests as chronic, intermittent or persistent pain. It worsens with exertion and improves with rest. Ankylosing spondylitis is prevalent in young men, with a wide range of pain, related to climate and seasons. Patients with low back pain should consult a doctor in time to clarify the cause and treatment.