Warmth in the hearts of hands and feet at night may be a symptom caused by yin deficiency and fire exuberance (deficiency of yin essence in the body, resulting in hyperactivity of deficiency fire), which may be due to stasis of blood. Yin deficiency and fire is defined as deficiency of yin and fluid, and hyperactive deficiency fire, which is characterized by heartburn and insomnia, dry mouth and throat, night sweating (abnormal sweating after going to sleep, and sweating stops after waking up), spermatorrhea, flushing on both cheekbones, and five heartburns and heat (heat in the heart of the two hands and the heart of the two feet, and self-consciousness of heart and chest irritation and heat). In this case, the main focus is on nourishing Yin and lowering fire, which can be treated with medicines such as Liu Wei Di Huang Wan and Zuo Gui Wan. When blood stasis blocks the liver, the manifestation of heat in the heart of hands and feet at night can also occur, and can be treated with Chai Hu Qing Bone San with additions and subtractions. If there is fever in the heart of the hands and feet at night, it is recommended to go to the regular hospital for diagnosis and treatment in time to avoid delaying the condition.