Hepatitis B interferon does not turn negative, does not mean in vain, because interferon can inhibit viral replication, to avoid causing other complications. Interferon is a kind of glycoprotein, with anti-virus, anti-tumor, immune regulation and inhibition of cell proliferation, applicable to acute hepatitis C, chronic hepatitis C and chronic hepatitis B treatment; at present, there is no drug can completely eliminate the hepatitis B virus, so interferon treatment of hepatitis B is not the main purpose of clearing the virus that is to turn negative, but to curb the replication of the virus. Through the application of interferon, other serious consequences induced by the replication of hepatitis B virus can be suppressed, including hepatitis B fibrosis, cirrhosis, and even liver cancer. Common adverse effects of interferon include headache, fever, fatigue and myalgia, etc. It should be noted that interferon is contraindicated in people who are allergic to interferon. In addition, the application of interferon has certain risks, need to get the guidance of specialists, not blindly use their own medicine.