Stage 2 highly differentiated bile duct adenocarcinoma can be treated by surgery to relieve the discomfort. Highly differentiated bile duct adenocarcinoma stage 2 belongs to cholangiocarcinoma, patients need to go to hepatobiliary surgery department as early as possible to treat the disease through surgery. Cholangiocarcinoma is a kind of malignant tumor occurring in bile duct system, and it has many clinical symptoms, such as abdominal pain, nausea, fever, etc. Patients are advised to pay attention to it, and go to Hepatobiliary Surgery Department to do relevant examination, such as ultrasonography, MRI, pancreatico-cholangiography, etc., and then treat the disease through surgical treatment or neoadjuvant chemotherapy. When high differentiated bile duct adenocarcinoma occurs, it is suggested that patients should choose regular hospitals to do a good job in the examination and treatment of the disease, so as to avoid delaying the condition.