Neurogenic postural hypotension, also known as idiopathic upright hypotension, is a rare and specific multisystemic degenerative disease. Autonomic abnormalities are the predominant clinical feature of this hypotension, which may also present with cerebellar ataxia, Parkinson’s syndrome, pyramidal fasciculations, and muscle atrophy. The etiology of neurogenic postural hypotension is not very clear, but it may be caused by degenerative lesions of the central nerve or peripheral autonomic nerves, resulting in central or peripheral autonomic dysfunction, and degeneration of the preganglionic fibers of the lateral horn neurons in the thoracic segment of the spinal cord, which can lead to upright hypotension. Early postural adjustments can have a good effect, such as elevating the head when lying down, wearing elastic tights or elastic stockings can reduce the depression of venous return when the patient is upright, and sitting up from bed or getting down slowly, and then slowly getting up after moving both lower limbs can reduce the attack. Selective peripheral sympathetic nervous system receptor antagonists can improve the general condition of the disease.