Hypofractionated squamous skin cancer should be positively surgically excised, and radiotherapy and other treatment methods should be considered if it cannot be operated. Hypofractionated squamous skin cancer belongs to malignant tumors with high malignancy degree in skin cancer, which occurs in the elderly and has certain correlation with long-term exposure to sunlight. Early stage cancers are mainly resected by surgery, which is often able to be completely resected and achieve better therapeutic effect. For the middle and late-stage lesions are too big to be completely removed, or there are lymph nodes and distant metastases and other conditions that are not suitable for surgery, radiotherapy and other treatments can be considered to inhibit the growth of the tumor and prolong the survival period. It is recommended that patients actively cooperate with doctors to avoid delaying the condition.