Mycoplasma cultures that are positive for deconjugated urea are generally considered for genitourinary mycoplasma infections, most commonly nongonococcal urethritis. Ureaplasma deconjugatum, is closely associated with human genitourinary tract infections. Mycoplasma solani is one of the common parasites of the human genitourinary tract, which can cause disease in specific environments, and is one of the pathogens that cause nongonococcal urethritis. Mycoplasma culture is positive for Ureaplasma solani, and Mycoplasma urealyticum infection of the genitourinary tract is considered. Mycoplasma urealyticum positive is most commonly associated with non-gonococcal urethritis, and if the infection is upstream, it can cause prostatitis or epididymitis in men, vaginitis, cervicitis in women, endometritis, pelvic inflammatory disease, salpingitis, etc., and it can also infect the fetus leading to miscarriage and preterm delivery. Mycoplasma culture is positive, asymptomatic people can not be treated, it is recommended that appropriate exercise to increase immunity after review. If symptoms occur, according to the results of the drug sensitivity test, under the guidance of the doctor to use macrolides such as erythromycin, azithromycin, etc. for treatment. Mycoplasma culture is positive for urea, it is recommended to go to the hospital to complete the examination, and follow the doctor’s instructions to standardize the treatment.