Painful urination in elderly women may be caused by urethritis, urinary stones, urinary tract tumors, etc. Oral medication, surgery, radiotherapy or chemotherapy can be chosen according to the different causes of the disease. 1. Urethritis: Urethritis can cause painful urination in elderly women due to inflammation stimulating the mucosa of the urethra, which can be treated by drinking more water and taking oral antibiotics such as levofloxacin and cefaclor under the guidance of a doctor. 2. Urolithiasis: Urolithiasis can cause bladder and urethra mucosa damage when embedded, causing urinary pain in elderly women, which can be treated by drinking more water, transurethral cystoscopy stone removal or lithotripsy. 3. Urological tumors: Urological tumors can also damage the urethral mucosa and cause urinary pain in elderly women, which can be treated through surgery to remove the tumor, radiotherapy, chemotherapy and other comprehensive treatments after clear diagnosis by urologists. Once elderly women have urinary pain, they should go to the hospital in time, and after diagnosis by professional doctors, they should follow the doctor’s instruction to carry out targeted treatment.