Painful subxiphoid thyroiditis can be treated with nonsteroidal anti-inflammatory drugs and glucocorticoids as prescribed by your doctor. Subacute thyroiditis is a localized inflammation of the thyroid gland caused by a viral infection, mainly seen in middle-aged women, manifested by fever and neck pain. It is a self-limiting disease, which means that the disease will get better on its own when it progresses to a certain extent. If the symptoms are mild, non-steroidal anti-inflammatory drugs can be used to control the symptoms. More severe symptoms can be relieved with glucocorticoids, such as prednisone acetate tablets. Meanwhile, thyroid hormone replacement therapy can be used in symptomatic patients during hypothyroidism. In conclusion, it is still recommended to visit an endocrine specialist as soon as possible for suboptimal pain and regular treatment under the guidance of a specialist.