Sotossyndrome, or cerebralgigantism, cerebralgigantismsyndromeinchildhood, also known as childhood giant brain syndrome ( macrencephalysyndrome, Sotos syndrome, is a syndrome in which the skeletal development grows too fast, the head is huge, and the intellectual development is delayed during infancy and school-age children. How to effectively prevent pediatric macrocephaly syndrome? The syndrome is clinically characterized by significant growth of body development in the neonatal period with long head and giant brain, mental retardation, idiosyncratic facial features and abnormal limb morphology. Symptomatic treatment is the main focus, and long-term follow-up should be observed. In the neonatal period, jaundice is often delayed and requires active treatment such as phototherapy and comprehensive systemic examination; in the infant period, recurrent respiratory infections, epilepsy and malignant tumors are common, especially the incidence of tumors is significantly higher with age than in healthy people. Therefore, we should be highly vigilant and adhere to the follow-up; to around puberty because of the huge brain can have a vertical growth of facial length, affecting the development of teeth and other orthodontic treatment is required. Rehabilitation and special education should be designed and implemented for the child and continue throughout the life of the intervention. The final height of the child is unpredictable, but normalizes with age, with most abnormal growth ceasing around puberty. The prognosis for this condition is generally healthy beyond childhood. Pregnant women should avoid hazards as much as possible, including smoke, alcohol, drugs, radiation, pesticides, noise, volatile gases, toxic and heavy metals, and systematic screening for birth defects during prenatal care, including regular ultrasound, serological screening and, if necessary, chromosomal testing. In case of abnormal results, it is necessary to clarify whether the pregnancy should be terminated; the safety of the fetus in the womb; whether there are sequelae after birth, whether they are treatable, what the prognosis is, etc., and to take practical measures for diagnosis and treatment.