Hepatitis B virus DNA quantitative 3300U/ml needs treatment, the normal value of hepatitis B virus DNA is less than 50U/ml, 3300U/ml indicates that the hepatitis B virus is actively replicating in the body, the level of hepatitis B virus in the blood is high, hepatitis B is highly infectious, and antiviral treatment is needed. Hepatitis B DNA is mainly used to assess the level of viral replication in HBV-infected patients, and is an important indicator for the selection of indications for antiviral therapy and the judgment of therapeutic efficacy. Obtaining a sustained virologic response during antiviral therapy significantly controls the progression of cirrhosis and reduces the risk of hepatocellular carcinoma. Serum HBV DNA positivity is one of the indications for antiviral therapy. As long as the serum HBV DNA is positive, antiviral therapy is recommended regardless of the abnormalities of liver function, aminotransferase, and the status of HBeAg, and commonly used antiviral drugs include entecavir, tenofovir disoproxil fumarate, and so on. Hepatitis B virus DNA quantitative 3300U/ml, it is recommended to consult a doctor in time, and follow the doctor’s instructions for medication.